Historical foundations muriel t davisson and carol c linder 1 5 introduction 1 5 historical foundations 1 5 history of mouse genetics and research with the laboratory. Manipulating the mouse embryo cold spring harbor lab press. The laboratory mouse, second model is an entire book written by worldwide specialists. Rearrange individual pages or entire files in the desired order. Laboratory mice are usually of the species mus musculus. Revised to reflect advances since the first edition, the laboratory mouse, second edition continues to be the most accessible reference on the biology and care of the laboratory mouse.
Guidelines for the housing of rats in scientific institutions. Time approximately 45 minutes question what is the effect of the genes of the parental mice on the fur color of the offspring mice. However, development of the laboratory mouse as a research model accelerated with genetic experiments in the early 1900s. Get a printable copy pdf file of the complete article 183k, or click on a page image below to browse page by page. The jackson laboratory s mission performing research. Code of practice for the housing and care of laboratory. Reproductive biology of breeding mice womens health.
Enterotropic strains tend to spread quickly from mouse to mouse. Biology of the laboratory mouse mouse genome informatics. Swipe your chicago card university of chicago id through the reader to enter the mouse facility. This content was uploaded by our users and we assume good faith they have the permission to share this book. The laboratory mouse handbook of experimental animals. Fourcolor illustrated book with complete instruction on mouse surgery, anatomy, behavior and care of the mouse in laboratory research new chapters on new. The laboratory mouse and immunology the laboratory mouse mus mus musculus domesticus to give it its full name is the unsung hero of biology. By 1901, william castle, the greatgrandfather of mammalian genetics, recognized the potential of mice to test mendels theories. Mouse genetics student guide independence high school. This book, part of the highly successful handbook of experimental animals series, allows the user quick access to any point of interest on the mouse as an. Adding svgs to pdfs with python and reportlab the mouse. Additionally the laboratory mouse continues to play a widely publicized vital role in the human genome project.
The jackson laboratory handbook on genetically standardized mice. Nevertheless, it was not until clarence cook little developed the first inbred mouse strain, dba, in 1909 that the modern laboratory mouse. Do so by opening the white adobe acrobat app with the stylized, red a icon. Entering and exiting the gcis mouse facility entering the facility, suite, and preparing the hood 1. Guidelines for the housing of rats in scientific institutions animal welfare branch, nsw department of primary industrie s, locked bag 21, orange nsw 2800. History, development and genetics of the mouse as a laboratory model origin of the laboratory mouse and related historical foundations strain, stock and mutants mouse genomics generation of mouse mutants by sequence information driven and random mutagenesis the mouse. Infection of skin scratches and bite wounds with mouse or humanborne opportunistic microbes demands attention through a strict occupational medical treatment program national research council, 1997. The laboratory mouse was derived from the common house mouse, mus musculus. The laboratory mouse handbook of experimental animals among animals used in research, teaching and testing, mice are now widely recognized as the most important model for human diseases and disorders. Full text full text is available as a scanned copy of the original print version. With inclusions of the newly revised european necessities on laboratory animals, this may be probably the most current, worldwide authority on the care of mice in laboratory. The laboratory mouse, second edition is a comprehensive book written by international experts.
It will automatically rename the output to the same name as the input file, but with the pdf. Twocolor, userfriendly format combined with color plate sections. Mouse genetics student guide prelab information purpose explore the relationship between genotype and phenotype. Care of laboratory mice, rats, guinea pigs and rabbits mice and rats the laboratory mouse and rat are derived from a largely nocturnal burrowing and climbing ancestor who favoured building. The approximate age of mouse pups can be determined by their physical attributes during the irst two weeks of life. One of the most timeconsuming activities in research laboratories is looking.
Barthold center for comparative medicine schools of medicine and veterinary medicine university of california davis, ca muriel t. These have a primary tropism for the intestine and are excreted in feces. Most strains of mhv in animal houses are enterotropic strains. Pdf the laboratory mouse and wild immunology researchgate. These fancy mice then became subjects for research due to interest in the mechanisms of inheritance of these coat colors. Solutions should be isotonic same tonicity as blood. Pdf the laboratory mouse, mus musculus domesticus, has been the work horse of the very successful laboratory study of mammalian immunology. When you select pages, the pages are only removed from the combined pdf file. One of the most timeconsuming activities in research laboratories is looking up information specific to the species or strain of animal being used.
How to combine files into a pdf adobe acrobat dc tutorials. Analgesia anesthesia other agents administered carprofen. Use the smallest gauge of needle possible that allows accurate injection of the substance. A laboratory manual, fourth edition click here for more information or to buy the book. Put on a hairnet, face mask, disposable lab coat, and a pair of shoe covers. Normally laboratory mice have to be involved by means of professional handlingrestraint in order to perform all procedures necessary during husbandry andor experimentation. Full text is available as a scanned copy of the original print version. As a result, mouse colonies everywhere are expanding, and scientists who previously focused on other models are turning their attention to the mouse. Arrange and adjust the monitor, keyboard, mouse, documents, and other items at the workstation in a comfortable working position that suits the individuals needs before starting work, or. The laboratory mouse is a small mammal of the order rodentia which is bred and used for scientific research.
The mouse in biomedical research, 2nd edition volume i history, wild mice, and genetics edited by james g. Then click on file in the menu bar at the top of the screen, click on open. Mouse hepatitis virus mhv division of animal resources university of illinois, urbana background. Volume for substance administration use the smallest possible volume for injection. Electronic version of biology of the laboratory mouse edited by earl l. Fox division of comparative medicine, mit cambridge, ma stephen w. With inclusions of the newly revised european standards on laboratory animals, this will be the most current, global authority on the care of mice in laboratory research. Get comfortable using computers page 3 is an asterisk or can be used instead of a multiplication x. This is a free sample of content from manipulating the mouse embryo.